This course does not count toward a concentration in chemistry.

BIOC G4026y. Biochemistry of Nucleic Acids and Protein Synthesis. 4.5 pts. Not offered in 2009-2010. Prerequisites:BCHM G4021, or the equivalent, BIOC C3501.

Structure and organization of chromatin, nucleic acid hybridization and sequence complexity of DNA, DNA and RNA sequencing methods, current views of replication and repair, transcription and translation, regulation of nucleic acid and protein synthesis, recombinant DNA techniqes, gene transfer and gene duplication. Discussion of original papers and evaluation of experimental procedures and conclusions.

CHEM G9303x-G9303y (Section 1). Investigation of Special Problems in Chemistry. 1-12 pts. Points to be arranged.

Individualized research projects.

CHEM G9307x-G9307y (Section 1). Research for the Doctorate. 1-12 pts. Pass/Fail

Department's permission.

CHEM G4141x. Bioorganic Spectroscopy. 4.5 pts. Not offered in 2009-2010. Prerequisites: Elementary organic chemistry.

The combined use of UV/VIS, CD, IR, Raman, NMR in structural studies of natural products and interactions between ligands and their biopolymeric receptors. Application in biosynthesis. Various topics and techniques used in bioorganic chemistry, including photoaffinity labeling, G-protein coupled receptors, vision, memory, etc. Proton and carbon magnetic resonance; circular dichroism; combined usage with other spectroscopic methods as applied to structure determination of complex organic molecules.

CHEM G4147x. Advanced Organic Chemistry. 4.5 pts. Prerequisites: Elementary organic and physical chemistry.

The mechanisms of organic reactions, structure of organic molecules, and theories of reactivity. How reactive intermediates are recognized and mechanisms are deduced using kinetics, stereochemistry, isotopes, and physical measurements.

CHEM G4172y. Biorganic Topics. 4.5 pts. Prerequisites: Elementary organic chemistry.

Recommended preparation: advanced organic chemistry. Various topics in bioactive molecules in the field centered on natural-products chemistry, metabolic transformations, and enzyme mechanisms. Biosysnthesis of natural products and some other bioorganic topics.

CHEM G8148x. Synthetic Methods in Organic Chemistry I. 4.5 pts.

Construction, analysis and strategies for the synthesis of complex natutal products.

CHEM G8149y. Synthetic Methods in Organic Chem. II. 4.5 pts. Prerequisites:CHEM G8148.

Construction, analysis, and strategies for the synthesis of complex natural products.

CHEM G8310y. Transition Metals in Synthesis. 2.5 pts.

Recent advances in the development of homogeneous catalysis for selective organic synthesis. Emphasis on both mechanistic and synthetic aspects.

CHEM G8311x. Natural Products Chemistry. 2.5 pts. Not offered in 2009-2010.

Topics from recent trends in natural products chemistry, especially in ligand/receptor interactions.

CHEM G8313x. Modern Molecular Photochemistry of Organic Compounds. 2.5 pts.

Review of principles of the mechanisms of organic photochemical reactions.

CHEM G8314y. Molecular Recognition and Self-Assembly. 2.5 pts. Not offered in 2009-2010.

The chemistry of designing, synthesizing, and studying molecules that self-assemble.

CHEM G8316y. Supramolecular Chemistry. 2.5 pts. Prerequisites:G4147 or permission from the instructor.

Intermolecular interactions are at the structure-reactivity and structure-function relations of many issues in material sciences and biological chemistry. This course will describe the fundamental concepts and methodologies of the field and review its development over the past several decades. Emphasis will be placed on guest-host systems which can be developed based on the paradigm of the chemistry of enzymes.

CHEM G4103x. Advanced Inorganic Chemistry. 4.5 pts. Prerequisites: Elementary organic chemistry. (Some background in inorganic and physical chemistry is helpful but not required.)

Main group and transition metal organometallic chemistry: bonding, structure, reactions, kinetics, and mechanisms.

CHEM G8104y. Structure Determination in Inorganic Chemistry. 2.5 pts. Not offered in 2009-2010.

The determination of structures by diffraction methods, focusing on single crystal X-ray diffraction, is described. Emphasis is placed on a critical evaluation of published data.

CHEM G8105y. Bioinorganic Chemistry. 2.5 pts. Not offered in 2009-2010.

Coordination chemistry of proteins and nucleic acids and their synthetic analogs.

CHEM G8106y. Kinetics. 2.5 pts. Not offered in 2009-2010.

Kinetics and mechanisms of inorganic reactions.

CHEM G8107y. Physical Methods in Inorganic Chemistry. 2.5 pts. Not offered in 2009-2010.

Advanced topics in spectroscopic methods as applied to transition metal complexes.

CHEM G8108y. Group Theory. 2.5 pts. Not offered in 2009-2010.

Chemical applications of group theory: structure, bonding and spectroscopy. Ligand field and molecular orbital theories.

CHEM G8110x. Applications of Transition-Metal Organometallics to Polymer Chemistry. 2.5 pts. Not offered in 2009-2010.

The use of transition-metal complexes as catalysts for olefin polymerization, and for atom transfer and chain transfer during free-radical polymerizations.

CHEM G8111y. Applications of NMR Spectroscopy to Inorganic Chemistry. 2.5 pts.

The use of multinuclear NMR spectroscopy in the determination of the structures of inorganic molecules and the use of dynamic NMR spectroscopy (variable temperature NMR and magnetization transfer techniques) to provide information concerned with reaction mechanisms.

CHEM G8130x. The Chemistry of Nanocrystals. 2.5 pts.

This course will provide a discussion of the thermodynamics and kinetics of colloidal crystallization and stabilization, the physical properties of quantum confined semiconductor and metal nanocrystals, methods of nanocrystal characterization, and examples of nanocrystals in technological applications. Prospective students should be familiar with basic principles of quantum mechanics, thermodynamics of phase transitions, and inorganic chemistry â€" particularly molecular orbital theory. Undergraduate students interested in this course should obtain approval from the instructor prior to registering.

CHEM G4221x. Quantum Chemistry. 4.5 pts. Prerequisites: Elementary physical chemistry.

Basic quantum mechanics: the Schrodinger equation and its interpretation, exact solutions in simple cases, methods or approximation, angular Mementum and electronic spin, and an introduction to atomic and molecular structure.

CHEM G4230x. Statistical Thermodynamics.. 4.5 pts. Prerequisites: Elementary physical chemistry. Corequisites:CHEM G4221

Topics include the classical and quantum statistical mechanics of gases, liquids, and solids.

CHEM G6231y. Intermediate Statistical Mechanics. 2.5 pts. Prerequisites: Chemistry G4221 and G4230

Phase transitions and critical phenomena; renormalization group methods; classical theory of fluids.

CHEM G6241y. Chemical Dynamics. 2.5 pts. Not offered in 2009-2010. Prerequisites: Chemistry G4221 or the equivalent.

Theory of the rates and temperature dependence of chemical reactions in gases and liquids.

CHEM G6242y. Interfaces and Condensed Phases. 2.5 pts. Not offered in 2009-2010. Prerequisites: Chemistry G4221 and G4230 or their equivalents.

Elements of the physical chemistry and electronic structure of interfaces and solid materials with application to organic conductors and semiconductors.

CHEM G6251y. Spectroscopy. 2.5 pts. Prerequisites: Chemistry G4221 or the equivalent.

Principles of the interaction of molecules with radiation. Applications of spectroscopy to elucidate molecular structure and bonding.

CHEM G8223y. Quantum Chemistry, III. 2.5 pts. Not offered in 2009-2010. Prerequisites: Chemistry G6222

Atomic and molecular quantum mechanics: electron correlation, configuration interaction, many-body perturbation theory, density functional methods.

CHEM G8232y. Advanced Statistical Mechanics. 2.5 pts. Not offered in 2009-2010. Prerequisites: Chemistry G4221 and G4230 or their equivalents.

Stochastic processes; Brownian motion; Langevin equations and fluctuation-dissipation theorems; reaction rate theory; time correlation functions and linear response theory.

CHEM G8252y. Special Topics in Physical Chemistry. 2.5 pts. Not offered in 2009-2010. Prerequisites: Chemistry G4221 or the equivalent.

Problems and methods in areas of current research interest.

CHEM G4131x. Introductory Quantum Chemistry. 4.5 pts. Not offered in 2009-2010. Prerequisites:CHEM 3079 and CHEM 3080.

An intermediate level treatment of quantum mechanics as it pertains to molecular spectroscopy. Topics include perturbation theory, the Born Oppenheimer approximation; Franck Condon factors; infrared, Raman, and fluorescence spectroscopy; correlation functions; and the density matrix.

CHEM G4145y. NMR Spectroscopy. 1 pt. Prerequisites: Elementary organic chemistry.

Introduction to theory and practice of NMR spectroscopy. Instrumental aspects, basic NMR theory, NOE, and a survey of 2D methods are covered.

BIOC G4170y. Biophysical Chemistry. 4.5 pts. Prerequisites: Elementary physical and organic chemistry.

Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance, analysis of the conformation of proteins and nucleic acids; hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure.

BIOC W4510x. Molecular Systems Biology I. 4.5 pts. Prerequisites: One year of Biology, Chemistry and Physics. Courses taken at CU are recommended, but AP courses may be sufficient with permission from the instructors.

This course will present a quantitative description of the molecular networks that underlie the myriad phenotypes in living cells, from yeast to human. Topics covered include various high-throughput genomics technologies (DNA sequencing, mRNA expression profiling, ChIP, proteomics), mathematical models of transcriptional and post-transcriptional regulatory networks, quantitative genetics of gene expression, synthetic biology and the world of RNA structure, dynamics and function. These topics will be integrated with introductory lectures on molecular and structural biology, thermodynamics, statistics and machine learning. The course is intended for advanced undergraduates as well as beginning graduate students in Biology, Chemistry, Physics, Engineering and Computer Science. Taught by research scientists active in various areas of systems biology, the course is highly interdisciplinary and rooted in recent research.

BIOC W4511y. Molecular Systems Biology II. 4.5 pts. Prerequisites: One year of Biology and one year of Chemistry (AP in High School and/or at Columbia) or permission from the instructor.

A quantitative description of the molecular networks that underlie the myriad phenotypes in living cells. Topics covered include various high-throughput technologies (genome sequencing, DNA microarrays, proteomics and phenotypic drug screening), transcriptional and posttranscriptional regulatory networks, synthetic biology and neural networks. These will be integrated with introductory lectures on molecular and structural biology, thermodynamics, statistics and maching learning.

CHEM G6222y. Quantum Chemistry II. 4.5 pts. Not offered in 2009-2010. Prerequisites: Quantum Chemistry G4221

Atomic and molecular quantum mechanics: fundamentals of electronic structure, many-body wave functions and operators, Hartree-Fock and density functional theory, the Dirac equation.