GEND G4005. Introduction To Mathematical Genetics. 3 pts. Prerequisite: calculus. Introductory courses in probability are recommended but are not required. Basic concepts of genetics and population genetics. Genetic linkage. Models of disease transmission. While general genetic principles are covered, emphasis is on human genetics and on human genetic linkage. Offered every other Spring starting Spring 2005.

GEND G4027. Principles of Developmental Biology. 3 pts. Required for first-year Genetics and Development students. Open to students from all departments, but students from outside the Genetics Department should consult the instructor before registering. The course emphasizes the molecular control of vertebrate embryogenesis. Divided into three main areas: early embryogenesis, developmental neurobiology, and the development and differentiation of specialized organs or lineages. A combination of faculty lectures and presentations by participating students.

GEND G4050. Advanced Eukaryotic Molecular Genetics. 4 pts. Required for second year Genetics and Development students. Open to all students. Prerequisite: at least one graduate-level biochemistry or molecular biology course, and instructor's permission. Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problem sets on the current literature.

GEND G4501-G4502. Methods In Genetics and Development. 4 pts. Open only to students in the department. A survey of laboratory methods used in research. Students rotate through the major laboratories of the department.

GEND G6210. Genetic Approaches To Biological Problems. 3 pts. Required for first year Genetics and Development students. Open to all students. Designed to illustrate how genetic systems have played a fundamental role in our understanding of basic biological problems: mitosis and meiosis, chromosomal linkage and mapping, consequences of chromosomal rearrangements, mechanisms of recombination and gene conversion, the use of mutants to study gene structure, regulation and the cell cycle, uses of recombinant DNA in genetic analysis, and the genetic analysis of development in Drosophila.

GEND G6211. Genetic Approaches To Biological Problems. 3 pts. Required for first-year Genetics and Development students. Continuation of Genetics G6210. Basic principles and current areas of interest in mouse and human genetics. An introduction to mouse genetics; X-chromosome inactivation and genomic imprinting; genetic manipulation of the mouse; genetics of mouse coat color; genetics of sex determination; the mouse T-complex; human linkage analysis; somatic cell genetics; physical mapping of the human genome; cytogenetics; Huntington's disease; muscular dystrophy and Alzheimer's disease; and gene therapy.

GEND G9321-G9322. Seminar In Genetics and Development. 1-2 pts. Open only to students in the department. Presentation of selected research topics.

GEND G9355. Special Research. Points to be arranged Prerequisite: member of the department's permission