Columbia College

Columbia College Science Scholars

Ethan Chen

My research project will study cell invasion using multi-cell spheroids implanted in collagen. I will create co-culture spheroids that consist of two different cell lines – one invasive and one non-invasive. After implanting the spheroids, I will image them to see how far the cells have invaded. Creating co-culture spheroids would bridge the gap between homogenous mono-culture spheroids and heterogenous primary tumors. I hope to use this model to understand how invasive cells cause non-invasive cells to invade, and how we can prevent this. Understanding how invasive cells lead non-invasive cells to invade can also help us develop better cancer therapies.